Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host
Figure 9
(a) Recovery of B. malayi preadults from different groups of Bm-iPGM immunized and control mice. Parasites were collected by washing the peritoneal cavity of infected BALB/c mice. Immunization of mice with Bm-iPGM resulted in marked reduction in worm establishment (). Statistical analysis was done using one-way ANOVA followed by Newman-Keuls Multiple Comparison Test. Each bar represents mean ± S.E. of worms recovered from five animals. (b) Assessment of microfilarial density in tail blood of Bm-iPGM immunized adjuvant and control groups. Mf count was initiated from day 90 till day 180 p.c. Control and adjuvant groups exhibited elevated levels of blood Mf density. However, Mf levels remained low in Bm-iPGM immunized group and significant reduction in microfilarial density (/72.396%) on day 180 (p.c.) was observed in immunized animals. Each point represents a value obtained from six animals.
