Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host

Table 1

Adult parasite recovery and female worm fecundity from control and Bm-iPGM immunized Mastomys.

Animal groups	Number of animals	Adult parasite counts/animal		Adult worm recovery (mean ± S.E.)		% reduction in worm burden		% female parasite sterilization
		Day 30 p.c.	Day 180 p.c.	Day 30 p.c.	Day 180 p.c.	Day 30 p.c.	Day 180 p.c.	Day 180 p.c.
PBS	6/6	30, 27, 32, 28, 18, 24	♀24, 25, 15, 14, 21, 20; ♂9, 7, 8, 8, 9, 5	26.50±2.02	27.50±1.95	0.0	0.0	18.50
Adjuvant	6/6	18, 22, 26, 27, 23, 31	♀22, 19, 18, 12, 21, 15; ♂13, 10, 11, 8, 11, 10	24.50±1.83	28.33±2.15	7.54	−3.01	20.51
Bm-iPGM	6/6	8, 8, 10, 5, 9, 12	♀6, 9, 6, 7, 4, 5; ♂4, 3, 3, 2, 6, 2	8.66±0.95^∗∗∗	9.5±0.67^∗∗∗	67.29	65.45	69.97

Statistically significant values were obtained in Bm-iPGM immunised groups as compared to the control groups. ^∗∗∗𝑃<0.001. Values represented are mean ± S.E.