Supplementation of T₃ Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis

Figure 4

Effect of PTU-induced hypothyroidism and its reversal by T₃ upon mitochondrial ROS and ROS-metabolizing enzymes. (a) Hydrogen peroxide content. (b) Se-dependent glutathione peroxidase (GPx) activity. (c) Se-independent GPx activity in the mitochondrial matrix fraction isolated from liver of rats. Data are means ± S.D. of five animals/group. Statistical significance is denoted by ^∗𝑃<0.01 and ^∗∗𝑃<0.001 compared to euthyroid rats; ^‡𝑃<0.001 compared to hypothyroid rats.

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