Supplementation of T₃ Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis

Figure 5

Effect of PTU-induced hypothyroidism and its reversal by T₃ upon mitochondrial thiol content. (a) Protein-bound thiol content in submitochondrial particles. (b) Protein-bound thiol content in mitochondrial matrix fraction. (c) Nonprotein thiol content in mitochondrial matrix fraction isolated from liver of rats. Data are means ± S.D. of five animals/group. Statistical significance is denoted by ^∗𝑃<0.01, ^∗∗𝑃<0.005, and ^∗∗∗𝑃<0.001 compared to euthyroid rats; ^‡𝑃<0.005 compared to hypothyroid rats.

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