Supplementation of T₃ Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis

Figure 6

Effect of PTU-induced hypothyroidism and its reversal by T₃ upon mitochondrial membrane-bound respiratory enzyme complexes. (a) NADH:duroquinone (DQ) oxidoreductase activity. (b) Succinate:2,6-dichlorophenolindophenol (DCPIP) oxidoreductase activity. (c) Succinate:cytochrome c oxidoreductase activity. (d) ATPase activity in the submitochondrial particles isolated from liver of rats. Data are means ± S.D. of five animals/group. Statistical significance is denoted by ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 compared to euthyroid rats; ^‡𝑃<0.05 and ^‡‡𝑃<0.001 compared to hypothyroid rats.

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