Research Article
Amylenes Do Not Lead to Bacterial Mutagenicity in Contrast to Structurally Related Epoxides
Table 1
Reverse mutations for positive and negative controls.
| | Strain | | TA98 | TA100 | YG7108 |
| | Solvent control | −S9 |
18 ± 6 () | 120 ± 17 () | 20 ± 6 () | | +S9 | 20 ± 7 () | 145 ± 19 () | 26 ± 9 () | |
Gas-tight | −S9 | 19 ± 7 () | 128 ± 18 () | 24 ± 9 () | | +S9 | 21 ± 4 () | 141 ± 18 () | 23 ± 6 () | | Not gas-tight: | | | | | | 3-NBA, 5 ng | −S9 | 709 ± 328 () | | | | MMS, 200 g | −S9 | | 1516 () | 805 ± 283 () | | MMS, 500 g | −S9 | | 968 ± 175 () | | | MMS, 1000 g | −S9 | | 1543 ± 40 () | | | 2-AF | +S9 | 843 ± 228 () | 646 ± 117 () | | | 2-AA, 5 g | +S9 | | 781 ± 52 () | | | 2-AA, 10 g | +S9 | 486 ± 175 () | | | | NDEA, 500 g | +S9 | | | 225 ± 85 () | | NDEA, 1000 g | +S9 | | | 414 ± 360 () |
|
|
3-NBA: 3-nitrobenzanthrone; 2AF: 2-aminofluorene; 2-AA: 2-aminoanthracene; MMS: methyl methanesulfonate; NDEA: -nitrosodimethylamine.
|
