Transforming Growth Factor-Beta (TGF-β) Signaling in Paravertebral Muscles in Juvenile and Adolescent Idiopathic Scoliosis

Table 4

GO molecular functions of TGFβ related genes differentiating muscular transcriptomes from concave and convex sides of the curve in JIS: juvenile idiopathic scoliosis and AIS: adolescent idiopathic scoliosis. value result of nonparametric Mann-Whitney test. FC: fold change.

Function	JIS				AIS
	Gene		FC	Regulation	Gene		FC	Regulation
Transcription factor activity	NR3C1	0.04	1.56	up	TOX4	0.01	1.17	down
	SMAD3	0.02	1.18	up
	TRIM33	0.03	1.38	down
	ZBTB7B	0.02	1.26	down
Growth factor activity	BMP2K	0.04	1.12	down	GDF15	0.03	1.17	up
	BMP6	0.02	1.17	down
	INHBA	0.01	1.18	down
Receptor activity	TACD2	0.02	1.22	down	ITGB4	0.01	1.09	up
					ITGB5	0.01	1.15	up
Calcium ion binding	FKBP1A	0.01	1.37	up
	PCDH1	0.01	1.3	down
Calmodulin binding					LTBP3	0.03	2.34	up
					LTBP4	0.01	1.5	up
					MYL6	0.03	1.53	up
Protein binding	FBXL12	0.01	1.31	up
	ASPP1	0.02	1.23	down
Hormone activity					PTHR	0.02	1.1	down
Cysteine type peptidase activity	UCHL5	0.03	1.56	up
Oxidoreductase activity	EGLN1	0.04	1.52	up
Str. constituent of cytoskeleton	KRT15	0.01	1.26	down
Ubiquitin protein ligase activity					SMURF1	0.03	1.04	down
Nucleotide kinase activity					MAGI2	0.02	1.2	down
Transmembrane receptor protein-kinase activity					TGFBR2	0.01	1.13	up
Unclassified	FA175	0.02	1.26	up
	TTC17	0.04	1.21	up
	WIPI3	0.02	1.19	up
	TMEM1	0.03	1.1	up
	UNC45	0.03	1.43	down
	DCAF7	0.01	1.23	down
	SH3D21	0.01	1.19	down
	RAB25	0.01	1.13	down
	L1TD1	0.02	1.05	down