Research Article
Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
Table 1
Inhibitory effect of indolylchalcone (5a–g) and pyrido[2,3-d]pyrimidine derivatives (7a–k) on hCA I and hCA II.
| Compound | hCA I IC50 (M) | hCA II IC50 (M) |
| 5a |
8.34 | 8.88 | 5b | 7.42 | 10.35 | 5c | 13.07 | 12.28 | 5d | 8.20 | 8.26 | 5e | 12.84 | 9.15 | 5f | 10.87 | 9.31 | 5g | 8.38 | 7.22 | 7a | 16.29 | 19.42 | 7b | 11.56 | 12.06 | 7c | 21.09 | 31.10 | 7d | 12.14 | 13.66 | 7e | 6.79 | 8.06 | 7f | 26.21 | 25.40 | 7g | 7.61 | 7.57 | 7h | 12.36 | 24.67 | 7i | 8.72 | 8.14 | 7j | 10.19 | 9.56 | 7k | 22.30 | 26.68 |
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