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BioMed Research International
Volume 2014, Article ID 598052, 8 pages
http://dx.doi.org/10.1155/2014/598052
Research Article

Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts

1Department of Radiation Oncology, William Beaumont Hospital, 3811 West Thirteen Mile Road, 105-RI, Royal Oak, MI 48073, USA
2Department of Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
3Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA

Received 22 November 2013; Accepted 28 March 2014; Published 28 April 2014

Academic Editor: Xin-yuan Guan

Copyright © 2014 Jiayi Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To determine the optimal timing and analytic method of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki). Results. Four xenografts had local failure (LF) and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.