Effects of Dietary Cholesterol and Its Oxidation Products on Pathological Lesions and Cholesterol and Lipid Oxidation in the Rabbit Liver

Table 1

Effect of dietary cholesterol and cholesterol oxidation products on liver lesions: pathological lesions in liver.

Dietary
CHO1 + COPs g/kg diet	6 weeks	12 weeks
0 g	0; 0; 0; 0	0; 0; 0; 0
1 g chol.	+; +; +; +	+; +; +; +
2 g chol.	+; ++; ++; ++++	++; ++; ++; +++
0.9 chol. + 0.1 COPs	+; +; +; +	+; +; +; +
0.8 chol. + 0.2 COPs	+; +; +; +	+; +; +; +
0.5 chol. + 0.5 COPs	+; +; +; +	+; +; +; +
1.6 chol. + 0.4 COPs	+; ++; +++; ++++	++; +++; +++; ++++
1.2 chol. + 0.8 COPs	+; +++; +++; ++++	++; +++; ++++; ++++

0: no abnormalities detected; +: mild vacuolation of hepatocytes in the periacinar region of the hepatic lobule; ++: mild vacuolation of hepatocytes in the periacinar and midzonal areas of the hepatic lobule; +++: moderate vacuolation of cells in the periacinar and midzonal areas of the hepatic lobule, with affected cells showing diffuse vacuolation of the cytoplasm; ++++: diffuse and severe vacuolation of hepatocytes in all areas of the hepatic lobule, with marked swelling of the hepatocytes.
¹CHO: natural cholesterol; COPs: cholesterol oxidation products.