|
| Author | Study design | AKI definition | Population | Biomarkers | Main findings |
|
Askenazi
et al. [43] | Nested case-control | AKIN | Very low birth weight infants
(n = 30, AKI = 9) | Urine NGAL and OPN | Urine biomarkers were higher in those with AKI. No information about early AKI diagnosis. |
|
Krawczeski
et al. [44] | Prospective cohort | AKIN | 374 infants (35 neonates, AKI = 8) undergoing cardiac surgery with CPB | Serum and urine NGAL | Serum and urine NGAL 2 h after CPB are early predictive biomarkers for AKI. |
|
Askenazi
et al. [37] | Nested case-control | SCr ≥1.7 mg/dL >72 h after birth or rising values >0.3 mg/dL within 48 h (AKIN) | Neonates birth weight > 2000 g, GA >34 weeks, 5-minute score Apgar ≤7
(n = 58, 9 neonates developed AKI) | Urine NGAL, OPN, uCysc, albumin, β2 microglobulin, epithelial growth factor, UMOD, and KIM-1 | Urine CysC, UMOD, and epithelial growth factor were higher in those with AKI. No information about early AKI diagnosis. |
|
| Li et al. [45] | Prospective cohort | SCr >1.5 mg/dL or pRIFLE | Nonseptic critically ill neonates
(n = 62, AKI = 11) | uCysC and uIL-18 | Urine CysC and IL-18 are predictive of AKI in nonseptic critically ill neonates. |
|
| Sarafidis et al. [46] | Prospective cohort | SCr ≥1.5 mg/dL >24 h or rising values >0.3 mg/dL from DOL 1 | 13 asphyxiated neonates and 22 nonasphyxiated
(n = 35, AKI = 8) | Serum CysC and NGAL
Urine CysC, NGAL, and KIM -1 | Serum NGAL and uNGAL and uCysC are higher in asphyxiated neonates, even in those not developing AKI. They had also provided an early AKI diagnosis. |
|
| Elmas et al. [47] | Case-control | pRIFLE or SCr ≥1.5 mg/dL on the first 3 days | Preterm neonates with RDS (n = 28, AKI = 8). Additional control group with 34 neonates without RDS nor AKI | Serum CysC | Serum CysC is an independent predictor of AKI in RDS neonates. |
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