Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase 1, and Mitochondria Copy Number Are Identified as Universal Biomarkers

Table 1

Summary list of identified potential biomarkers for PAHs exposure.

PAHs	Protein	Fold change
Benzopyrene	Vimentin	19.39
	Annexin A1	13.38
	Lamin-A/C	10.04
	NADPH: adrenodoxin oxidoreductase, mitochondrial isoform 2 precursor	5.3
	Squalene synthase	5.3
	Heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1	4.82
	T-complex protein 1 subunit theta	4.35
	Talin-1	4.35
Pentacene	Lamin-A/C	6.9
	DNA topoisomerase 2-alpha	6.38
	Annexin A1	6.38
	Poly[ADP-ribose] polymerase 1	5.85
	Squalene synthase	5.33
	Talin-1	5.33
	PREDICTED: u5 small nuclear ribonucleoprotein 200 kDa helicase-like, partial	4.81
Fluoranthene	Poly[ADP-ribose] polymerase 1	6.21
	Elongation factor 1-gamma	5.21
	Heat shock 70 kDa protein 1A/1B	5.21
	Heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1	5.21
	Probable ATP-dependent RNA helicase DDX5	5.21
	T-complex protein 1 subunit theta	5.21
Pyrene	Talin-1	16.82
	DNA topoisomerase 2-alpha	8.17
	Filamin-C isoform b	7.16
	E3 SUMO-protein ligase RanBP2	5.65
	CAD protein	5.14
	Poly[ADP-ribose] polymerase 1	5.14