A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians

Table 2

Distribution of genotypes and allele frequencies of the RFC-1 80G>A polymorphism in Alzheimer’s disease and control individuals.

Genotypes/alleles	AD patients 𝑛=192 (%)	Controls 𝑛=186 (%)	Crude OR (95% CI)	𝑃 value	Adjusted OR^a (95% CI)	𝑃 value
Genotypes
GG	53 (27.6)	49 (26.3)	1.00^b	—	1.00^b	—
GA	102 (53.1)	98 (52.7)	0.96 (0.59–1.55)	0.87	0.97 (0.58–1.62)	0.89
AA	37 (19.3)	39 (21.0)	0.88 (0.48–1.59)	0.66	0.94 (0.50–1.78)	0.86
AA + GA versus GG	139 (72.4)	137 (73.7)	0.94 (0.60–1.48)	0.78	0.96 (0.59–1.57)	0.89
Alleles
Allele G	0.54	0.53	1.00^b	—		—
Allele A	0.46	0.47	0.94 (0.71–1.25)	0.69	0.98 (0.72–1.32)	0.88

aAdjusted for age and gender.
^bReference value for OR.