A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians

Table 3

Correlation between RFC-1 80G>A genotypes and biochemical data.

	RFC-1 GG	RFC-1 GA	RFC-1 AA	RFC-1 GA + AA	𝑃 value^a
Total (𝑛=168)	39	95	34	129
Folate (ng/mL, mean ± SEM)	8.4±1.2	7.9±0.8	5.8±1.3	7.3±0.7	0.51
t-hcy (𝜇mol/L, mean ± SEM)	15.6±2.2	19.2±1.4	19.1±2.2	19.1±1.2	0.55
Vit. B12 (pg/mL, mean ± SEM)	462.1±39.3	421.7±24.9	366.1±41.6	406.9±21.4	0.63
AD (𝑛=104)	26	60	18	78
Folate (ng/mL, mean ± SEM)	8.1±1.5	7.4±1.0	4.9±1.8	6.8±0.9	0.65
t-hcy (𝜇mol/L, mean ± SEM)	16.1±3.5	22.6±2.2	22.1±4.1	22.5±2.0	0.50
Vit. B12 (pg/mL, mean ± SEM)	467.4±47.9	398.7±31.6	351.7±57.5	387.7±27.6	0.70
Controls (𝑛=64)	13	35	16	51
Folate (ng/mL, mean ± SEM)	8.3±2.2	8.5±1.3	7.1±1.9	8.1±1.1	0.75
t-hcy (𝜇mol/L, mean ± SEM)	13.2±1.4	14.3±0.8	16.6±1.2	15.0±0.7	0.17
Vit. B12 (pg/mL, mean ± SEM)	407.9±70.7	457.8±40.8	404.2±60.9	441±33.7	0.76

^a𝑃 value obtained with analysis of covariance using log transformed data and corrected for age and gender.