The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis

Table 1

Baseline features of included studies.

	Number of patients	Age	Female patients (%)	Diabetes mellitus (%)	Hypertension (%)	Hyperlipidemia (%)	Previous myocardial infarction (%)	Stable angina (%)	Acute coronary syndromes (%)	Myocardial infarction (%)
Angiolillo et al., 2007 [17]	173	67 ± 9	35	100	65	68	53	100	0	0
Bliden et al., 2007 [18]	100	66 ± 11	28	44	74	83	40	75	13	12
Breet et al., 2010 [19]	410	64 ± 11.3	26.8	17.3	72.4	77.6	58.3	100	0	0
Breet et al., 2010 [19]	920	64 ± 10.6	24.6	18.4	77.5	80.9	54.6	100	0	0
Buonamici et al., 2007 [2]	804	69 ± 11	25	21	62	50	26	34	39	27
Campo et al., 2010 [20]	826	68 ± 12	25.2	24	72.3	59.4	38.6	64.4	35.6 (low risk UA)	—
Chiu et al., 2011 [21]	144	65 ± 10	24	46.5	68.8	50	18	55	45	—
Collet et al., 2012 [7]	106	64 ± 10	23	25	58	56	46 (previous ACS)	0	100	0
Cuisset et al., 2006; 300 mg [22]	146	64.2 ± 10.3	21	29	58	56	44 (previous ACS)	0	100	100
Cuisset et al., 2006; 600 mg [22]	146	65.2 ± 12	27	33	56	55	45 (previous ACS)	0	100	100
Geisler et al., 2006 [23]	379	67.5 ± 10	26.9	34.7	79.6	60.6	45.5 (previous ACS)	54	45	—
Hochholzer et al., 2006 [24]	802	66.4 ± 9.1	21.8	24.8	82.3	nd	22.9	100	0	0
Jin et al., 2013 [25]	181	61.3 ± 12.1	16.6	24.9	39.5	95.5	3.9	0	100	100
D.-W. Park et al., 2011 [26]	809	64	33.2	30.5	66.3	45.4	7.2	100	—	—
Ko et al., 2011 [27]	222	63.3	31.5	32.0	72.1	46.8	5.9	100	—	—
Marcucci et al., 2012 [28]	1187	69	25.2	24.0	65.4	54.4	x	—	100	35
Motoda et al., 2012 [29]	450	71.1	31.5	42.8	74.0	60.2	31.1	100	—	—
K. W. Park et al., 2011 [30]	2546	61.7	29.9	28.5	58.9	61.0	5.9	55.6	44.4	—
Park et al. (ACS), 2013 [31]	1095	62	21	26	60	58	5	—	100
Park et al. (Stable Angina), 2013 [31]	1329	63	22	27	57	63	4	100	0	0
Parodi et al., 2011 [32]	1789	69	20	19.8	57.0	44.7	18.1	—	100	46
Patti et al., 2008 [33]	160	66	19.3	34.3	nd	74.3	28.1	45.7	54.3	—
Pettersen et al., 2012 [34]	1001	62.3	21.8	20.0	55.4	98.3	43.7	100	—	—
Price et al., 2011 [9]	380	68	23.2	28.9	88.2	35.5	31.6	100	—	—
Saia et al., 2013 [35]	833	67.6	25	28.7	69.3	67.5	32.0	0	0	100
Sibbing et al., 2009 [36]	1608	67.5	23.0	29.0	91.6	70.0	32.0	66.9	33	20
Sibbing et al., 2012 [37]	564	67.7	22.3	31.2	89.3	70.5	19.1	—	100	100
Siller-Matula et al., 2013 [38]	403	64.2	24.1	32.0	84.6	76.4	32.0	67	33.0	33.0
Stone et al., 2013 [39]	8665	63.6	26	32.4	79.6	74.3		48.3	27.6	24.1