Review Article

The Prognostic Impact of High On-Treatment Platelet Reactivity with Aspirin or ADP Receptor Antagonists: Systematic Review and Meta-Analysis

Table 2

Incidence of reactivity on aspirin, clopidogrel or both and kind of assays used.

Reactivity on aspirin and ADP receptor antagonists (%)Reactivity on aspirin (%)Reactivity on ADP receptor antagonists (%)Assays used

Angiolillo et al., 2007 [17]25Light Transmittance Aggregometry (ADP 20 mmol/L-upper quartile)
Bliden et al., 2007 [18]22 (LTA)
30 (TEG)
Light Transmittance Aggregometry (ADP 5 mmol/L)
Thromboelastography
Breet et al., 2010 [19]14.7 8.5 (aspirin only)25.1 (clopidogrel only)Verify Now aspirin/Verify Now P2Y12
Breet et al., 2010 [19]26.9 (LTA 5)
23.3 (LTA 20)
21.1 (LTA 5)
24.7 (LTA 20)
14.9 (LTA 5)
13.0 (LTA 20)
Light Transmittance Aggregometry
(ADP 5 mmol/L-LTA 5, and 20 mmol/L-LTA 20)
Buonamici et al., 2007 [2]13Light Transmittance Aggregometry (ADP 10 mmol/L)
Campo et al., 2010 [20]31521.6Verify Now aspirin/Verify Now P2Y12
Chiu et al., 2011 [21]33Platelet Function Analyzer-100
Collet et al., 2012 [7]2726Both ADP and arachidonic acid (AA) as agonists to explore the responses to clopidogrel and aspirin, respectively
Cuisset et al., 2006; 300 mg [22]25Light Transmittance Aggregometry (ADP 10 mmol/L)
Cuisset et al., 2006; 600 mg [22]15Light Transmittance Aggregometry (ADP 10 mmol/L)
Geisler et al., 2006 [23]5.8Light Transmittance Aggregometry (ADP 20 mmol/L)
Hochholzer et al., 2006 [24]50Verify Now P2Y 12
Jin et al., 2013 [25] nd55Multiple electrode aggregometry, Verify Now P2Y 12, Verify Now Aspirin
D.-W. Park et al., 2011 [26]40.9Light Transmittance Aggregometry (ADP 10 mmol/L)
Ko et al., 2011 [27]52ADP-induced platelet aggregation using a whole blood analyzer
Marcucci et al., 2012 [28]111744Multiple electrode aggregometry
Motoda et al., 2012 [29]50Multiple electrode aggregometry
K. W. Park et al., 2011 [30]25Verify Now P2Y 12
Park et al. (ACS), 2013 [31]63Verify Now P2Y 12
Park et al. (Stable Angina), 2013 [31]61Verify Now P2Y 12
Parodi et al., 2011 [32]26PFA 100
Patti et al., 2008 [33]32.1Verify Now P2Y 12
Pettersen et al., 2012 [34]20 Multiple electrode aggregometry (ADP)
Price et al., 2011 [9]36 Multiple electrode aggregometry (ADP)
Saia et al., 2013 [35]67Verify Now P2Y12
Sibbing et al., 2009 [36]82719Multiple electrode aggregometry (AA and ADP)
Sibbing et al., 2012 [37]
Siller-Matula et al., 2013 [38]
Stone et al., 2013 [39]42.7Verify Now aspirin/Verify Now P2Y12