Exploitation of a Very Small Peptide Nucleic Acid as a New Inhibitor of miR-509-3p Involved in the Regulation of Cystic Fibrosis Disease-Gene Expression
Figure 2
Superimposition of the MD average structures of miR-509-3p/PNA1 complex (a) and of miR-509-3p/PNA2 complex (b). Duplexes regions are represented in licorice coloured by atom type (carbon in cyan, oxygen in red, nitrogen in blue, phosphate in brown, and hydrogen in white). The miR-509-3p single strand regions are represented in spheres coloured by MD run (blue, run 1; green, run 2; red, run 3). (c) RMSD in Å, calculated on phosphates in the duplexes regions, among the average structures of the MD runs.
