Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B<sub>12</sub>) and Omega-3 Fatty Acids

<table>Role of altered micronutrients and omega-3 in the epigenetic regulation of developing fetus. The key metabolic components: THF: tetrahydrofolate, 5,10-MTHF: 5,10-methylene tetrahydrofolate; 5-MTHF: 5-methylene tetrahydrofolate; B<sub>12</sub>: vitamin B<sub>12</sub>; methionine; SAM: S-adenosyl methionine; SAH: S-adenosyl homocysteine; homocysteine; glutathione; PE-DHA: phosphatidylethanolamine with docosahexaenoic acid attached to position 2; PC-DHA: phosphatidylcholine with docosahexaenoic acid attached to position 2; DNA: deoxyribonucleic acid, histone. Key enzymes: MTHFR: methylene tetrahydrofolate reductase; MTR: methionine synthase; PEMT: phosphatidylethanolamine methyl transferase; CBS: cystathionine beta Synthase.</table>

BioMed Research International

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Figure 1

Figure 1: Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B<sub>12</sub>) and Omega-3 Fatty Acids 

Figure 1 | Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids 