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BioMed Research International
Volume 2014, Article ID 616817, 13 pages
http://dx.doi.org/10.1155/2014/616817
Review Article

Mannan-Binding Lectin in Cardiovascular Disease

1Department of Anesthesiology and Intensive Care, Polish Mother’s Memorial Hospital Institute, Rzgowska 281/289, 93-338 Łódź, Poland
2Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, Poland

Received 27 January 2014; Accepted 10 April 2014; Published 30 April 2014

Academic Editor: Robert M. Starke

Copyright © 2014 Izabela Pągowska-Klimek and Maciej Cedzyński. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host.