Biodistribution and SPECT Imaging Study of ^99mTc Labeling NGR Peptide in Nude Mice Bearing Human HepG2 Hepatoma

Table 2

Biodistribution data (%ID/g) of ^99mTc-NGR in HepG2 hepatoma tumor-bearing nude mice at 1, 4, 8, and 12 h postinjection (𝑛=5, mean ± SD).

	1 h	4 h	8 h	12 h	Blocking (1 h)
Blood	3.82±0.41	1.75±0.39	0.98±0.22	0.75±0.31	2.56±0.34
Heart	3.74±0.54	2.26±0.33	1.15±0.32	1.07±0.25	2.73±0.29
Lung	2.52±0.83	2.13±0.44	1.86±0.38	1.21±0.31	2.04±0.28
Liver	4.07±0.76	3.85±0.73	3.44±0.52	3.26±0.47	3.27±0.16
Kidney	7.93±2.13	7.03±0.95	6.21±0.43	5.96±0.41	5.03±0.97
Spleen	2.37±0.43	2.09±0.60	1.88±0.42	1.72±0.37	1.89±0.22
Stomach	3.07±0.56	2.20±0.26	1.61±0.39	1.56±0.32	3.41±0.31
Intestine	2.65±1.06	2.18±0.96	1.93±0.22	1.60±0.27	2.40±0.59
Muscle	0.53±0.33	0.46±0.11	0.43±0.14	0.39±0.22	0.48±0.27
Tumor	2.52±0.83	3.03±0.71	3.26±0.63	2.81±0.25	1.65±0.61
Tumor-to-normal tissue uptake ratio at 1 h postinjection
			T/M	4.75±0.91
			T/L	0.62±0.33
			T/K	0.32±0.15