Corneal Collagen Cross-Linking with and without Epithelial Removal: A Contralateral Study with 0.5% Hypotonic Riboflavin Solution

Table 4

Changes in topography features and wavefront aberrations during 12-month follow-up.

Parameter	CXL	Preoperative	1 m	6 m	12 m
Pachymetry (𝜇m)	Epithelium-on	459.50 ± 39.24	445.50 ± 48.92*	453.50 ± 47.02	458.25 ± 41.09
	Epithelium-off	463.05 ± 31.34	434.35 ± 33.90*	434.65 ± 31.85*	450.55 ± 32.14*
	𝑃 value	0.625	0.286	0.051	0.273
IRI (𝜇m)	Epithelium-on	34.25 ± 18.57	34.35 ± 18.66	33.65 ± 20.16	35.30 ± 20.09
	Epithelium-off	36.40 ± 13.10	38.05 ± 14.41	34.30 ± 13.91	33.15 ± 13.75
	𝑃 value	0.658	0.400	0.890	0.618
PE (𝜇m)	Epithelium-on	61.80 ± 24.90	62.25 ± 28.22	60.80 ± 24.11	63.00 ± 31.67
	Epithelium-off	60.65 ± 27.01	59.55 ± 27.30	63.90 ± 25.57	67.35 ± 28.60
	𝑃 value	0.865	0.717	0.611	0.486
Sim 𝐾1 (D)	Epithelium-on	47.89 ± 4.46	47.75 ± 4.05	47.83 ± 4.59	47.82 ± 4.10
	Epithelium-off	47.51 ± 2.98	47.52 ± 4.29	47.74 ± 4.43	47.25 ± 3.91
	𝑃 value	0.695	0.758	0.923	0.544
Sim 𝐾2 (D)	Epithelium-on	44.29 ± 2.77	44.34 ± 2.77	44.34 ± 2.77	44.47 ± 2.80
	Epithelium-off	44.71 ± 2.98	44.17 ± 3.25	44.17 ± 33.14	44.01 ± 2.97
	𝑃 value	0.614	0.996	0.776	0.452
𝐾 max (D)	Epithelium-on	52.68 ± 5.35	52.95 ± 5.38	52.40 ± 5.74	52.78 ± 5.55
	Epithelium-off	53.59 ± 4.72	53.40 ± 5.03	53.58 ± 5.59	53.28 ± 5.18
	𝑃 value	0.525	0.555	0.620	0.755
RMS: HOAs	Epithelium-on	1.18 ± 0.67	1.20 ± 0.60	1.20 ± 0.71	1.20 ± 0.77
	Epithelium-off	1.15 ± 0.55	1.15 ± 0.51	1.12 ± 0.57	1.07 ± 0.58
	𝑃 value	0.980	0.496	0.714	0.458
RMS: S3 + 5 + 7	Epithelium-on	1.15 ± 0.65	1.16 ± 0.59	1.12 ± 0.71	1.16 ± 0.76
	Epithelium-off	1.11 ± 0.55	1.03 ± 49	0.97 ± 0.43	0.99 ± 0.52
	𝑃 value	0.953	0.545	0.769	0.344

∗The difference between pre- and postoperative data was statistically significant (𝑃<0.05).