Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder

Table 4

Effect of thiazolidin-4-ones on body weight and food efficiency ratio in mice.

	NPD	HCD	Pioglitazone	Compound 2e	Compound 3a
Final body weight (g)	38.0 ± 2.1	41.2 ± 2.2	38.2 ± 1.4	37.6 ± 1.2	38.2 ± 2.1
Food efficiency ratio	0.0025 ± 0.005	0.0083 ± 0.006	0.0020 ± 0.005	0.0043 ± 0.011	0.071 ± 0.010^a,b

aRepresents 𝑃<0.05 as compared to NPD group (normal pellet diet).
^bRepresents 𝑃<0.05 as compared to HCD group (high carbohydrate diet).