Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
(a) Group 1 (Control): showing normal histologic appearance of rat liver tissue without sinusoidal congestion. Hepatocytes took the shape of cell cordons regularly localized around the vena centralis (H-E Bar 50 m). (b) Group 2: showing normal microscopic findings of liver tissue similar to group 1 (H-E Bar 50 m). (c) Group 3: dilatation and fibrosis in the vessel wall that located in the portal area of the liver sections. Star: mononuclear cell infiltration in the portal area, black arrow: hemorrhage in the vessel wall of portal area, and yellow arrow: hemorrhage and dilatation in sinusoids (Massone trichrome Bar 100 μm). (d) Group 3: Star indicates dilatation and congestion in sinusoids. Arrow indicates decreased glycogen storage in hepatocytes (PAS Bar 100 m). (e) Group 3: mononuclear cell infiltration in the portal area and dilatation in vessels together with thickening of the portal and periportal basement membrane (PAS Bar 100 m). (f) Group 4: slight sinusoidal congestion and thickening of the portal and periportal basement membrane and increased glycogen content following dexmedetomidine treatment (PAS Bar 100 m).
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