Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 621827, 11 pages
http://dx.doi.org/10.1155/2014/621827
Research Article

Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury

1Department of Pediatrics, Dicle University Medical School, Diyarbakir, Turkey
2Department of Anesthesiology, Dicle University Medical School, Diyarbakir, Turkey
3Department of Pulmonology, Dicle University Medical School, Diyarbakir, Turkey
4Department of Histology and Embryology, Dicle University Medical School, Diyarbakir, Turkey
5Department of Biochemistry, Dicle University Medical School, Diyarbakir, Turkey

Received 9 April 2014; Revised 8 July 2014; Accepted 17 July 2014; Published 6 August 2014

Academic Editor: Boris Jung

Copyright © 2014 Velat Şen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. von Dossow-Hanfstingl, “Advances in therapy for acute lung injury,” Anesthesiology Clinics, vol. 30, no. 4, pp. 629–639, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. J. Walkey, R. Summer, V. Ho, and P. Alkana, “Acute respiratory distress syndrome: epidemiology and management approaches,” Journal of Clinical Epidemiology, vol. 4, no. 1, pp. 159–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Fang, C. Bai, and X. Wang, “Bioinformatics insights into acute lung injury/acute respiratory distress syndrome,” Clinical and Translational Medicine, vol. 1, no. 9, pp. 1–9, 2012. View at Publisher · View at Google Scholar
  4. K. Raghavendran, G. S. Pryhuber, P. R. Chess, B. A. Davidson, P. R. Knight, and R. H. Notter, “Pharmacotherapy of acute lung injury and acute respiratory distress syndrome,” Current Medicinal Chemistry, vol. 15, no. 19, pp. 1911–1924, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Henrion, M. Schapira, R. Luwaert, L. Colin, A. Delannoy, and F. R. Heller, “Hypoxic hepatitis: clinical and hemodynamic study in 142 consecutive cases,” Medicine, vol. 82, no. 6, pp. 392–406, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Henrion, “Hypoxic hepatitis,” Liver International, vol. 32, no. 7, pp. 1039–1052, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. V. Fuhrmann, B. Jäger, A. Zubkova, and A. Drolz, “Hypoxic hepatitis—epidemiology, pathophysiology and clinical management,” Wiener Klinische Wochenschrift, vol. 122, no. 5-6, pp. 129–139, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Savransky, S. Bevans, A. Nanayakkara et al., “Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver,” American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 293, no. 4, pp. G871–G877, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Murthy and R. Singh, “Alpha 2 adrenoceptor agonist—dexmedetomidine role in anaesthesia and intensive care: a clinical review,” Journal of Anaesthesiology Clinical Pharmacology, vol. 25, no. 3, pp. 267–272, 2009. View at Google Scholar · View at Scopus
  10. C. Yang, P. Tsai, and C. Huang, “Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury,” Acta Anaesthesiologica Taiwanica, vol. 46, no. 4, pp. 151–159, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Phan and M. C. Nahata, “Clinical uses of dexmedetomidine in pediatric patients,” Pediatric Drugs, vol. 10, no. 1, pp. 49–69, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. P. P. Pandharipande, B. T. Pun, D. L. Herr et al., “Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial,” The Journal of the American Medical Association, vol. 298, no. 22, pp. 2644–2653, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. S. F. Holliday, S. L. Kane-Gill, P. E. Empey, M. S. Buckley, and P. L. Smithburger, “Interpatient variability in dexmedetomidine response: a survey of the literature,” Scientific World Journal, vol. 2014, Article ID 805013, 12 pages, 2014. View at Publisher · View at Google Scholar
  14. R. D. Sanders, P. Sun, S. Patel, M. Li, M. Maze, and D. Ma, “Dexmedetomidine provides cortical neuroprotection: Impact on anaesthetic-induced neuroapoptosis in the rat developing brain,” Acta Anaesthesiologica Scandinavica, vol. 54, no. 6, pp. 710–716, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Ayoglu, S. Gul, V. Hanci et al., “The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model,” Journal of Clinical Neuroscience, vol. 17, no. 6, pp. 770–773, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Taniguchi, Y. Kidani, H. Kanakura, Y. Takemoto, and K. Yamamoto, “Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats,” Critical Care Medicine, vol. 32, no. 6, pp. 1322–1326, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Gu, J. Chen, P. Xia, G. Tao, H. Zhao, and D. Ma, “Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice,” Acta Anaesthesiologica Scandinavica, vol. 55, no. 10, pp. 1272–1278, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Hanci, B. Erol, S. Bektaş et al., “Effect of dexmedetomidine on testicular torsion/detorsion damage in rats,” Urologia Internationalis, vol. 84, no. 1, pp. 105–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, “Free radicals and antioxidants in normal physiological functions and human disease,” The International Journal of Biochemistry and Cell Biology, vol. 39, no. 1, pp. 44–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. O. Erel, “A novel automated method to measure total antioxidant response against potent free radical reactions,” Clinical Biochemistry, vol. 37, no. 2, pp. 112–119, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Yang, P. Tsai, T. Wang, and C. Huang, “Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats,” Resuscitation, vol. 80, no. 10, pp. 1204–1210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Yang, C. Chen, P. Tsai, T. Wang, and C. Huang, “Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats,” Journal of Surgical Research, vol. 167, no. 2, pp. e273–e281, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Matute-Bello, G. Downey, B. B. Moore et al., “An official american thoracic society workshop report: features and measurements of experimental acute lung injury in animals,” The American Journal of Respiratory Cell and Molecular Biology, vol. 44, no. 5, pp. 725–738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. O. Erel, “A new automated colorimetric method for measuring total oxidant status,” Clinical Biochemistry, vol. 38, no. 12, pp. 1103–11111, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Aycicek, O. Erel, and A. Kocyigit, “Increased oxidative stress in infants exposed to passive smoking,” European Journal of Pediatrics, vol. 164, no. 12, pp. 775–778, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Mateos, E. Lecumberri, S. Ramos, L. Goya, and L. Bravo, “Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress: application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 827, no. 1, pp. 76–82, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Şahin, Z. Begeç, H. I. Toprak et al., “The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats,” Journal of Surgical Research, vol. 183, no. 1, pp. 385–390, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. V. Fuhrmann, N. Kneidinger, H. Herkner et al., “Impact of hypoxic hepatitis on mortality in the intensive care unit,” Intensive Care Medicine, vol. 37, no. 8, pp. 1302–1310, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Y. Chen, S. M. Wang, N. Li et al., “Creation of lung-targeted dexamethasone immunoliposome and its therapeutic effect on bleomycin -induced lung injury in rats,” PLoS ONE, vol. 8, no. 3, Article ID e58275, pp. 58–75, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Matute-Bello, C. W. Frevert, and T. R. Martin, “Animal models of acute lung injury,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 295, no. 3, pp. L379–L399, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Guzel, M. Kanter, B. Aksu et al., “Preventive effects of curcumin on different aspiration material-induced lung injury in rats,” Pediatric Surgery International, vol. 25, no. 1, pp. 83–92, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Henrion, “Ischemia/reperfusion injury of the liver: pathophysiologic hypotheses and potential relevance to human hypoxic hepatitis,” Acta Gastroenterologica Belgica, vol. 63, no. 4, pp. 336–347, 2000. View at Google Scholar · View at Scopus
  33. A. Tüfek, O. Tokgöz, I. Aliosmanoglu et al., “The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats,” International Journal of Surgery, vol. 11, no. 1, pp. 96–100, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Savransky, A. Nanayakkara, A. Vivero et al., “Chronic intermittent hypoxia predisposes to liver injury,” Hepatology, vol. 45, no. 4, pp. 1007–1013, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Arslan, F. M. Çomu, A. Küçük, L. Öztürk, and F. Yaylak, “Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury,” Libyan Journal of Medicine, vol. 7, no. 1, pp. 181–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Can, S. Gul, S. Bektas, V. Hanci, and S. Acikgoz, “Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury,” Acta Anaesthesiologica Scandinavica, vol. 53, no. 8, pp. 1068–1072, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Memiş, S. Hekimoǧlu, I. Vatan, T. Yandim, M. Yüksel, and N. Süt, “Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients,” British Journal of Anaesthesia, vol. 98, no. 4, pp. 550–552, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. U. Koca, Ç. G. Olguner, B. U. Ergür et al., “The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis,” The Scientific World Journal, vol. 2013, Article ID 292687, 11 pages, 2013. View at Publisher · View at Google Scholar
  39. A. Sezer, D. Memiş, U. Usta, and N. Süt, “The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study,” Turkish Journal Of Trauma & Emergency Surgery, vol. 16, no. 2, pp. 108–112, 2010. View at Google Scholar
  40. J. Peng, T. Cui, F. Huang et al., “Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, kupffer cell activation, and endotoxin receptors expressions,” Journal of Pharmacology and Experimental Therapeutics, vol. 344, no. 3, pp. 646–654, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Liu, G. Wang, G. Chen et al., “Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis,” BMC Complementary and Alternative Medicine, vol. 12, article 51, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. J. LeCouter, D. R. Moritz, B. Li et al., “Angiogenesis-independent endothelial protection of liver: role of VEGFR-1,” Science, vol. 299, no. 5608, pp. 890–893, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Shibuya, “Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis,” Angiogenesis, vol. 9, no. 4, pp. 225–230, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. E. Taniguchi, S. Sakisaka, K. Matsuo, K. Tanikawa, and M. Sata, “Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats,” Journal of Histochemistry and Cytochemistry, vol. 49, no. 1, pp. 121–129, 2001. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Enomoto, Y. Nishikawa, Y. Omori et al., “Cell biology and pathology of liver sinusoidal endothelial cells,” Medical Electron Microscopy, vol. 37, no. 4, pp. 208–215, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. B. Donahower, S. S. McCullough, R. C. Kurten et al., “Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity,” American Journal of Physiolog: Gastrointestinal and Liver Physiology, vol. 291, no. 1, pp. G102–G109, 2006. View at Publisher · View at Google Scholar · View at Scopus