Factors Determining Disease Duration in Alzheimer’s Disease: A Postmortem Study of 103 Cases Using the Kaplan-Meier Estimator and Cox Regression

Table 3

Results of the Cox proportional hazard model analysis for demographic, apolipoprotein E (Apo E) score, overall severity of neuropathology, and comorbidity (the frequency of neurological and nonneurological comorbidities present in each case).

Variable	𝛽	SE	𝑡	Wald	𝑃
Patient age	−0.005	0.01	0.47	0.99	0.64
Disease onset (all cases)	0.049	0.01	4.12	16.98	0.008**
Disease onset; (minus PSEN cases)	0.055	0.012	4.75	22.61	<0.001
Brain weight	0.001	0.0009	0.62	0.38	0.54
Apo E score	0.079	0.27	0.29	0.08	0.77
Number of areas affected	−0.002	0.056	0.04	0.001	0.97
Overall severity score	−0.011	0.058	0.19	0.03	0.85
Neurological comorbidity	0.131	0.136	0.96	0.93	0.33
Nonneurological comorbidity	0.032	0.081	0.40	0.16	0.70

𝛽: regression coefficient; SE: standard error; 𝑃: probability; ∗∗𝑃<0.01.