Preparation of Naringenin/β-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats
Figure 5
Naringenin/β-CD complex significantly inhibits the protein expression of key mediators involved in the pathogenesis of CNV in rats. (a)–(f) are western blot analyses for protein levels of VEGF, COX-2, PI3K, p38MAPK, MMP-2, and MMP-9 and their quantification. β-Actin was used as an invariant control for equal loading. Group 1: normal rats; group 2: CNV rats without treatment; group 3: CNV rats with naringenin treatment; group 4: CNV rats with naringenin/β-CD complex treatment. Data are expressed as mean ± SD; versus group 1, versus group 1, versus group 2, and versus group 2.