Figure 6: Comparison of confidence intervals between INST-13C-MFA and conventional 13C-MFA. (a) 95% confidence intervals of four representative fluxes were compared between conventional 13C-MFA (red) and INST-13C-MFA (blue). Black triangles indicate the actual values. (b) Shapes of reoptimized sum of squared difference (SSD) determined by the grid search. The red and blue lines show the results of conventional 13C-MFA and INST-13C-MFA, respectively. The horizontal lines represent the threshold value for the 95% confidence intervals.