OpenMebius: An Open Source Software for Isotopically Nonstationary ¹³C-Based Metabolic Flux Analysis

Table 1

Configuration of TCA cycle model.

FluxID	Rxns	Net flux	Carbon transitions
R1	Subs_PYR_EX → PYR	0	abc → abc
R2	PYR → ACCOA + Ind_CO2	0	abc → bc + a
R3	ACCOA + OAA → IsoCit	0	ab + cdef → fedbac
R4	IsoCit → AKG + Ind_CO2	0	abcdef → abcde + f
R5	AKG → Sym_SUC + Ind_CO2	0	abcde → abcd + e
R6	Sym_SUC → OAA	1	abcd → abcd
R7	PYR + Ind_CO2 → OAA	2	abc + d → abcd
R8	AKG → [AKG_B]	0
R9	OAA → [OAA_B]	0
R10	OAA → [LYS_B]	0
R11	PYR → [PYR_B]	0
R12	PYR → [LYS_B]	0
R13	PYR → [VAL_B]	0
R14	Subs_GLU_EX → AKG	0	abcde → abcde
R15	OAA → Sym_SUC	1	abcd → abcd
R16	OAA → PYR + Ind_CO2	2	abcd → abc + d