Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice

Figure 2

The effects of a combination of 0.5% lidocaine and 0.5% QX-222 on spontaneous pain behaviors. 15 min before treatment, injection of a combination of 0.5% lidocaine and 0.5% QX-222 inhibited spontaneous pain (a). The cumulative licking/biting times of mice in the 0.5% lidocaine + 0.5% QX-222 group were significantly decreased in early and late phase (b). , versus formalin ().

(a)

(b)