Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice

Figure 3

The effects of a combination of 0.5% lidocaine and 0.5% QX-222 on evoked pain behaviors. On the first day after treatment, CFA-treated mice exhibited significant decrease of PWL and MWT; coapplication of lidocaine and QX-222 did not attenuate the thermal hyperalgesia and mechanical allodynia in the CFA-treated mice ((a) and (b)). , versus control ().

(a)

(b)