Irritation score (intracutaneous) in male rabbits.
Animal no.
Test and control articles*
Total
Total score
Irritation**score
Total irritation score
Mean#
Difference of mean##
Pre
Time (hour) after administration
24
48
72
1 2 3
Physiological saline extract of Fish collagen
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0.00 0.00 0.00
0.00
0.00
0.00
1 2 3
Physiological saline extract (control)
0 0 0
0 0 0
0 0 0
0 0 0
0 0 0
0.00 0.00 0.00
0.00
0.00
1 2 3
Sesame oil extract of Fish collargen
0 0 0
6 5 7
6 5 7
6 5 7
18 15 21
1.20 1.00 1.40
3.60
1.20
−0.24
1 2 3
Sesame oil extract (control)
0 0 0
5 8 9
5 8 9
5 7 9
15 23 27
1.00 1.53 1.80
4.33
1.44
Notes: *Each test and control article was administered to 5 sites per animal.
**Total score [erythema and eschar formation () and edema formation () of 24, 48, and 72 hours after administration of per animal]/15 [3 grading periods (24, 48, and 72 hours after administration) × 5 administered sites].
#Total irritation score/3 animals.
##Mean (each test article) − Mean (each control article).
