Biological Safety of Fish (Tilapia) Collagen

Table 4

Body temperature in male rabbits.

Test article	Animal no.	Rectal temperature (°C)									Temperature rise (°C)	Total^# (°C)	Pyrogenicity
		Before administration		Control temperature	After administration
		1st	2nd		3rd	4th	5th	6th	7th	8th
Physiological saline extract of fish collagen	1	38.8	38.7	38.75	38.9	39.1	39.2	39.2	39.2	39.2	0.45	1.15	−
	2	39.0	39.0	39.00	39.3	39.4	39.4	39.4	39.3	39.2	0.40
	3	38.7	38.7	38.70	38.9	38.8	38.8	39.0	39.0	39.0	0.30

Notes: ^#The total of the temperature rise.
−: Negative.