Affects CHIKV replication through a RNase L-dependent pathway.
Ability of OAS3 to inhibit alphavirus growth may be important for the development of antiviral molecules against CHIKV.
Cannot rule out the possibility that OAS3-mediated inhibition of CHIKV was also due to a block early in virus life cycle, for example, viral entry and uncoating of virus particles.
CHIKV utilizes IMPDH activity for its growth and multiplication which is a potential and effective target to prevent its infection.
It would be useful to explore similar findings by targeting IMPDH in case of other alphaviruses which are more lethal than chikungunya like Sindbis virus, Semliki forest virus, and so forth.
Critical antiviral host protein that controls CHIKV infection and provides a preclinical basis for the design of effective control strategies against CHIKV.
Large gaps in our understanding of the precise mechanisms at play for viperin to exert such a wide variety of roles within the cell.