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BioMed Research International
Volume 2014 (2014), Article ID 632570, 7 pages
Research Article

Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

1Departament of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, UNESP, 14801-902 Araraquara, SP, Brazil
2Departament of Clinical Analysis, School of Pharmaceutical Sciences, UNESP, 14801-902 Araraquara, SP, Brazil, Brazil
3Institute of Environmental, Chemistry and Pharmaceuticals Sciences, Federal University of São Paulo (UNIFESP), 09972-270 Diadema, SP, Brazil
4Ugelstad Laboratory, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway

Received 12 November 2013; Revised 9 January 2014; Accepted 31 January 2014; Published 19 March 2014

Academic Editor: Philippe Humbert

Copyright © 2014 Marcela B. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with ( = RP-loaded opaque liquid system and = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. In vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. In vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. The results showed that the incorporation of RP in LCS improved the safety profile of the drug. In vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.