The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in <i>Mycobacterium tuberculosis</i> by Traditional Chinese Medicine

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Compounds</td><td align="center">Plants</td><td align="center">-PLP1</td><td align="center">-PLP2</td><td align="center">Dock score</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Saussureamine C</td><td align="center"><i>Saussurea lappa</i> Clarke</td><td align="center">77.12</td><td align="center">69.11</td><td align="center">134.058</td></tr><tr><td align="left">Methyl-3-O-feruloylquinate</td><td align="center"><i>Phellodendron amurense</i> Rupr.</td><td align="center">94.26</td><td align="center">93.3</td><td align="center">132.524</td></tr><tr><td align="left">Labiatic acid</td><td align="center"><i>Rosmarinus officinalis</i> L.</td><td align="center">89.42</td><td align="center">89.08</td><td align="center">128.436</td></tr><tr><td align="left">Dihydropteroate<svg height="13.75" id="M1" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 7.7375002 13.75" width="7.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg></td><td align="center"> </td><td align="center">96.11</td><td align="center">79.59</td><td align="center">29.675</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="13.75" id="M2" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 7.7375002 13.75" width="7.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g>
</svg>Control.<br/></td></tr></table>

Scoring functions of the top three compounds and the inhibitors of folC.

BioMed Research International

tab1

Table 1

Table 1: The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in <i>Mycobacterium tuberculosis</i> by Traditional Chinese Medicine 

Table 1 | The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine 