Research Article
Xanthan Gum as an Adjuvant in a Subunit Vaccine Preparation against Leptospirosis
Table 2
Protection conferred by immunization and culture isolation and histology among survivors.
| | Vaccine preparation | Exp. number
| % Protection 
(number/total) | % Culture positive | Evidence of lesions (%) | | Alveolar haemorrhage | Cell degeneration | Leukocyte infiltration |
| | rLigANI | 1 | 0 (0/6) | NA | NA | NA | NA | | rLigANI-Al | 1 | 66.7 (4/6)* | 100 (4/4) | 100 (4/4) | 75.0 (3/4) | 100 (4/4) | | rLigANI-CpG | 1 | 16.7 (1/6) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | | rLigANI-Xa | 1 | 100 (6/6)* | 100 (6/6) | 100 (6/6) | 33.3 (2/6) | 100 (6/6) | | 2 | 100 (6/6)* | 66.7 (4/6) | 100 (6/6) | 16.7 (1/6) | 33.3 (2/6) | | rLigANI-CpG-Xa | 1 | 100 (6/6)* | 100 (6/6) | 100 (6/6) | 33.3 (2/6) | 100 (6/6) | | Bacterin | 1 | 100 (6/6)* | 0 (0/6) | 100 (6/6) | 0 (0/6) | 0 (0/6) | | 2 | 100 (6/6)* | 0 (0/6) | 100 (6/6) | 0 (0/6) | 0 (0/6) | | Xanthan-PBS | 1 | 16.7 (1/6) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | | 2 | 0 (0/6) | NA | NA | NA | NA | | Al-PBS | 1 | 0 (0/6) | NA | NA | NA | NA | | CpG-PBS | 1 | 0 (0/6) | NA | NA | NA | NA |
|
|
ND: not determined; NA: not applicable; Al: Alhydrogel; Xa: Xanthan.
*Statistically significant compared to the relevant control, Fishers exact test, .
|
