Apoptotic and Inhibitory Effects on Cell Proliferation of Hepatocellular Carcinoma HepG2 Cells by Methanol Leaf Extract of Costus speciosus
Figure 5
Effect of methanolic extract of Costus speciosus leaves on cell cycle distribution. Methanolic extract or sorafenib treatment significantly increased the proportion of S phase while significant decrease of G1/G0 phase. (a) Cell cycle analysis by flow cytometry. After exposure of HepG2 cells to 100 μg/mL of the methanol extract or sorafenib for 24 h, cells were harvested, stained with propidium iodide, and analyzed by flow cytometry. Flow cytometric histograms are representative of two separate experiments. (b) Percentage of cell populations. The data are from one of two independent experiments with similar results. Data are expressed as mean ± SD (). Columns not sharing the same superscript letter differ significantly (%).
