BioMed Research International / 2014 / Article / Fig 2

Review Article

E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications

Figure 2

E-cadherin regulated signaling pathways involved in gastric cancer, including Wnt/β-catenin pathway, Rho GTPases, NF-κB pathway, EGFR, and Rac-MAPK signaling. Activation of these pathways leads to increase in cell proliferation, decrease in cell apoptosis, cell migration, and inflammation associated gastric cancer development.

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