Maternal Obesity and Occurrence of Fetal Macrosomia: A Systematic Review and Meta-Analysis

Table 4

Association between maternal obesity and fetal overgrowth (odds ratios for individual studies and meta-analysis results).

Outcome of subgroup title	Study	Calculated unadjusted odds ratio	Reported adjusted odds ratio
Large for gestational age (≥90th percentile)	Hoff et al., 2009 [42]	0.86 (0.37, 2.02)	N/A
	Leung et al., 2008 [45]	3.19 (2.63, 3.87)	3.39 (2.78, 4.13)
	Nohr et al., 2008 [46, 47]	1.97 (1.81, 2.14)	N/A
	Getahun et al., 2007 [49]	2.06 (1.97, 2.15)	N/A
	Narchi and Skinner, 2010 [54]	2.47 (2.11, 2.89)	1.4 (1.3, 1.5)
	Magann et al., 2011 [61]	2.72 (2.07, 3.58)	3.10 (2.32, 4.15)
	Lumme et al., 1995 [62]	2.78 (2.12, 3.64)	2.3 (1.7, 3.0)
	Bodnar et al., 2010 [67]	4.33 (3.89, 4.82)	N/A
	Voigt et al., 2008 [69, 70]	2.54 (2.39, 2.52)	N/A
	Salihu et al., 2009 [43]	1.96 (1.93, 2.00)	N/A
	Jensen et al., 2003 [51]	1.61 (1.27, 2.04)	N/A
	Athukorala et al., 2010 [53]	2.26 (1.52, 3.36)	2.08 (1.47, 2.93)
	Langer et al., 2005 [63]	1.83 (1.48, 2.26)	N/A
	Total	2.13  (2.10, 2.16)	N/A
Macrosomia (birth weight ≥ 4000 g)	Bhattacharya et al., 2007 [24]	2.17 (1.89, 2.49)	N/A
	El-Gilany and Hammad, 2010 [66]	7.01 (1.52, 32.33)	N/A
	Stepan et al., 2006 [52]	2.86 (2.28, 3.60)	N/A
	van Wootten and Turner, 2002 [59]	4.72 (0.90, 24.75)	N/A
	Mantakas and Farrell, 2010 [65]	2.20 (1.74, 2.79)	1.9 (1.5, 2.5)
	Le Thai et al., 1992 [68]	23.88 (3.09, 184.72)	N/A
	Brennand et al., 2005 [71]	3.76 (2.34, 6.03)	3.73 (2.41, 5.05)
	Crane et al., 2009 [44]	1.86 (1.47, 2.36)	N/A
	Sukalich et al., 2006 [50]	1.78 (1.29, 2.46)	1.6 (1.2, 2.0)
	Jensen et al., 2003 [51]	1.43 (1.15, 1.79)	2.2 (1.6–3.1)
	Baeten et al., 2001 [23]	1.95 (1.84, 2.07)	2.1 (1.9, 2.3)
	Driul et al., 2008 [56]	2.58 (1.07, 6.19)	2.58 (1.08, 6.21)
	Roman et al., 2007 [57]	3.11 (2.28, 4.22)	3.1 (2.2, 4.3)
	Sahu et al., 2007 [58]	N/A	N/A
	Rode et al., 2005 [33, 60]	1.9 (1.53, 2.32)	1.8 (1.4–2.2)
	Langer et al., 2005 [63]	1.89 (1.43, 2.50)	N/A
	Total	2.01  (1.93, 2.11)	N/A
Macrosomia (birth weight ≥ 4500 g)	Khashan and Kenny, 2009 [48]	3.23 (2.86, 3.66)	2.71 (2.38, 3.07)
	Clausen et al., 2005 [55]	3.72 (1.86, 7.41)	4.3 (1.5, 12.1)
	Mantakas and Farrell, 2010 [65]	3.72 (2.08, 6.66)	8.7 (3.6–21.0)
	Brennand et al., 2005 [71]	2.94 (1.40, 6.16)	2.95 (1.87, 4.03)
	Crane et al., 2009 [44]	1.87 (1.28, 2.73)	N/A
	Athukorala et al., 2010 [53]	4.68 (2.03, 10.80)	4.54 (2.01, 10.24)
	Lumme et al., 1995 [62]	2.23 (1.45, 3.45)	1.8 (1.1, 2.8)
	Jensen et al., 1999 [64]	2.02 (1.21, 3.38)	N/A
	Total	3.01 (2.71, 3.34)	N/A