Mas-Mediated Antioxidant Effects Restore the Functionality of Angiotensin Converting Enzyme 2-Angiotensin-(1–7)-Mas Axis in Diabetic Rat Carotid
Figure 2
Concentration-response curves for angiotensin-(1–7) in endothelium-intact (E+) or -denuded (E−) carotid rings from control or diabetic rats, over the precontraction induced by phenylephrine (PE). Representative traces from angiotensin-(1–7)-evoked relaxation in E+ control (a) or diabetic (b) rat carotid. Effect of the in vitro pretreatment with A779, PD123,319 or hydroxocobalamin in carotid rings from control (c) or diabetic (d) rats. Effect of the in vitro pretreatment with apocynin, tiron, PEG-catalase, or the chronic (in vivo) treatment with angiotensin-(1–7) in carotid rings from control (e) or diabetic (f) rats. Angiotensin-(1–7) Emax in carotid from control or diabetic rats before or after the in vitro pretreatment with A779, PD123,319, hydroxocobalamin (g), apocynin, tiron, or PEG-catalase or the chronic (in vivo) treatment with angiotensin-(1–7) (h). The values are significantly different (; ) from nonpretreated E+ () or E− () carotid rings from nontreated control rats, from nonpretreated E+ (#) or E− (##) carotid rings from nontreated diabetic rats, or from PEG-catalase pretreated E+ (†) carotid rings from nontreated control rats.
