Mas-Mediated Antioxidant Effects Restore the Functionality of Angiotensin Converting Enzyme 2-Angiotensin-(1–7)-Mas Axis in Diabetic Rat Carotid

Table 3

Blood pressure (BP), carotid blood flow (F), and carotid resistance (R) from control or diabetic rats.

Rats	Cardiovascular parameters
	BP (mmHg)	F (mL/min)	R (U)
Nontreated control	81.7±5.4	6.11±0.48	14.1±2.3
Nontreated diabetic	99.2±8.1	2.37±0.21^∗	44.6±3.2^∗
DX600-treated control	76.4±6.2	2.09±0.17^∗	41.9±3.5^∗
DX600-treated diabetic	89.2±7.5	2.13±0.19	45.2±4.2
Angiotensin-(1–7)-treated control	79.5±6.1	5.76±0.32	13.2±2.9
Angiotensin-(1–7)-treated diabetic	97.0±9.1	6.29±0.51^#	15.0±2.1^#
A779-treated control	81.1±7.4	1.99±0.14^∗	40.2±4.3^∗
A779-treated diabetic	98.7±8.3	2.44±0.23	42.4±4.1
Angiotensin-(1–7) + A779-treated control	75.6±7.0	2.05±0.19^∗,†	38.2±3.8^∗,†
Angiotensin-(1–7) + A779-treated diabetic	99.5±9.2	1.97±0.11^†	46.3±4.7^†

The values are significantly different (𝑃<0.01; 𝑛=5) from nontreated control rats (∗), nontreated diabetic rats (#), or the respective rats treated with angiotensin-(1–7) (†).