In Vivo Protection against Strychnine Toxicity in Mice by the Glycine Receptor Agonist Ivermectin
Figure 4
Time course of strychnine and ivermectin effects. (a) Time course of strychnine and ivermectin action. For strychnine, lethality (% of animals) within 0–5 and 5–10 min is plotted. After 30 min, no effects of strychnine were observed. For ivermectin, the -fold increase in survival time >6 min was plotted relative to control animals which received only vehicle. (b) One- and two-compartment models of distribution of strychnine and ivermectin in tissue.
