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BioMed Research International
Volume 2014 (2014), Article ID 640909, 5 pages
http://dx.doi.org/10.1155/2014/640909
Research Article

Analysis of the Associations between Vitamin D and Albuminuria or β-Cell Function in Chinese Type 2 Diabetes

Endocrine & Metabolism Department, Peking University People’s Hospital, Beijing 100044, China

Received 12 December 2013; Revised 18 March 2014; Accepted 31 March 2014; Published 23 April 2014

Academic Editor: Ali Rizvi

Copyright © 2014 Xiaoling Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the associations of 25-(OH)D and β-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results. Comparison between patients with and without 25-(OH)D deficiency indicated that, compared with patients with 25-(OH)D ≥ 50 nmol/L, patients with 25-(OH)D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) ( mg/g versus  mg/g). Multiple regression analysis indicated that 25-(OH)D was independently and negatively correlated with urine ACR (, 95%CI 0.972–0.999, ), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH)D ( nmol/L versus  nmol/L, ). Analysis of the associations of 25-(OH)D and β-cell function or insulin resistance showed that 25-(OH)D may not correlate with β-cell function or insulin resistance. Conclusion. 25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with β-cell function or insulin resistance.