Chondroitin Sulfate Proteoglycans: Structure-Function Relationship with Implication in Neural Development and Brain Disorders
Figure 4
(a) The structure of ACAN core protein in complex with tenascin-R FnIII repeats 3–5, as revealed by the crystal structure 1TDQ [78]. The tenascin-R fragment is represented as a light blue transparent surface that covers its backbone represented with the same color. ACAN core protein is represented with magenta and the three Ca2+ ions coordinated by ACAN are represented with yellow. (b) Detail on ACAN core protein (represented with magenta). The Ca2+ ions are represented with yellow and the residues involved in coordinating them are represented with green. Figures were made by Mernea M. using the free license software Pymol [52].
