BioMed Research International

Review Article

Chondroitin Sulfate Proteoglycans: Structure-Function Relationship with Implication in Neural Development and Brain Disorders

Table 1

Chondroitin sulfate enzymes in human.
Enzymes AbbreviationChromosomal location
Glycosyltransferases involved in synthesis of the tetrasaccharide linkage region
XylosyltransferaseXylT16p12.3
,4-Galactosyltransferase-IGalT-I5q35.2-q35.3
,3-Galactosyltransferase-IIGalT-II1p36.33
,3-Glucuronyltransferase-IGlcAT-I11q12.3
Glycosyltransferases involved in synthesis of the repeating disaccharide region of CS chains
Chondroitin synthaseChSy-115q26.3
ChSy-25q23.3
ChSy-37q36.1
Chondroitin polymerizing factorChPF2q35
Chondroitin transferaseChGn-18p21.3
ChGn-210q11.21
Sulfotransferases and epimerases
Chondroitin 4-O-sulfotransferaseC4ST-112q
C4ST-27p22
C4ST-33q21.3
Dermatan 4-O-sulfotransferaseD4ST-115q15.1
Chondroitin 6-O-sulfotransferaseC6ST-110q22.1
Uronyl 2-O-sulfotransferaseUST6q25.1
GalNAc 4-sulfate 6-O-sulfotransferaseGalNAc4S-6ST10q26
Glucuronyl C-5 epimeraseDS-epi16q22
DS-epi218q22.1