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BioMed Research International
Volume 2014, Article ID 645056, 5 pages
Research Article

Study on the Relationship between Manganese Concentrations in Rural Drinking Water and Incidence and Mortality Caused by Cancer in Huai’an City

1Huai’an City Center for Disease Prevention and Control, Huai’an, Jiangsu 223001, China
2The Department of No-Communicable Diseases Control and Prevention, Huai’an City Center for Disease Prevention and Control, 118 Huaihai North Road, Huai’an, Jiangsu 22300, China
3China Research Academy of Environmental Science, Beijing 100012, China
4Department of Environmental Engineering, Beijing Petrochemical College, Beijing 102617, China

Received 14 February 2014; Accepted 30 July 2014; Published 3 November 2014

Academic Editor: Xin-yuan Guan

Copyright © 2014 Qin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Cancer is a significant disease burden in the world. Many studies showed that heavy metals or their compounds had connection with cancer. But the data conflicting about the relationship of manganese (Mn) to cancer are not enough. In this paper, the relationship was discussed between Mn concentrations in drinking water for rural residents and incidence and mortality caused by malignant tumors in Huai’an city. Methods. A total of 158 water samples from 28 villages of 14 towns were, respectively, collected during periods of high flow and low flow in 3 counties of Huai’an city, along Chinese Huai’he River. The samples of deep groundwater, shallow groundwater, and surface water were simultaneously collected in all selected villages. Mn concentrations in all water samples were determined by inductively coupled plasma-mass spectrometry (ICP-MS 7500a). The correlation analysis was used to study the relationship between the Mn concentration and cancer incidence and mortality. Results. Mn concentrations detectable rate was 100% in all water samples. The mean concentration was 452.32 μg/L ± 507.76 μg/L. There was significant difference between the high flow period and low flow period (, ) and also among deep groundwater, shallow groundwater, and surface water (, ). The ratio of superscale of Mn was 75.32%. There was significant difference of Mn level between samples in the high flow period and low flow period (, ) and also among deep groundwater, shallow groundwater, and surface water (, ). And also we found that, during the low flow period, Mn concentration has positive correlation with cancer incidence and mortality; for a 1 μg/L increase in Mn concentration, there was a corresponding increase of 0.45/100000 new cancer cases and 0.35/100000 cancer deaths (). Conclusions. In Huai’an city, the mean concentration of Mn in drinking water was very high. Mn concentration correlated with cancer incidence and mortality.