A-FABP Concentration Is More Strongly Associated with Cardiometabolic Risk Factors and the Occurrence of Metabolic Syndrome in Premenopausal Than in Postmenopausal Middle-Aged Women
Table 4
Logistic regression models for the unadjusted and adjusted associations of A-FABP with MetS, MetS components, and cardiometabolic risk factors.
Unadjusted OR per unit (95% CI)
OR per unit adjusted for age and BMI
Multivariate-adjusted OR per unit (95% CI)&
PRE
POST
PRE
POST
PRE
POST
MetS
1.06@ (1.01–1.10)
1.0 (0.98–1.02)
1.02 (0.98–1.06)
0.97 (0.95–1.01)
1.02 (0.97–1.04)
0.91 (0.79–1.06)
Glucose ≥ 5.6 mmol/L
1.0 (0.97–1.03)
0.99 (0.97–1.02)
0.99 (0.94–1.03)
0.98 (0.97–1.01)
0.99 (0.94–1.03)
0.99 (0.95–1.02)
HDL-C < 1.29 mmol/L
1.17# (1.09–1.25)
1.03* (1.01–1.06)
1.13# (1.04–1.24)
1.02 (0.99–1.04)
1.08# (1.03–1.18)
1.02 (0.99–1.05)
TG ≥ 1.7 mmol/L
1.0 (0.97–1.04)
1.0 (0.97–1.03)
1.0 (0.95–1.05)
1.0 (0.97–1.03)
0.94 (0.92–1.07)
1.01 (0.97–1.04)
WC ≥ 80 cm
1.20# (1.08–1.33)
1.09# (1.05–1.22)
1.23# (1.09–1.40)
1.09# (1.05–1.24)
1.24# (1.09–1.61)
1.07# (1.03–1.27)
Elevated BP (≥130/≥85 mmHg)!
1.04* (1.01–1.07)
1.0 (0.99–1.01)
0.99 (0.96–1.03)
0.98 (0.96–1.02)
0.98 (0.95–1.02)
0.98 (0.96–1.02)
HOMA ≥ 3.4
1.04* (1.01–1.07)
1.01 (0.98–1.04)
1.01 (0.97–1.06)
0.98 (0.94–1.03)
0.99 (0.95–1.02)
0.97 (0.90–1.04)
TC/HDL-C ≥ 4
1.08# (1.03–1.135)
1.0 (0.98–1.02)
1.14# (1.05–1.25)
1.0 (0.98–1.03)
1.14# (1.03–1.26)
1.01 (0.98–1.03)
TG/HDL-C ≥ 1.3
1.04@ (1.01–1.07)
1.01 (0.99–1.04)
1.06@ (1.0–1.11)
1.0 (0.98–1.04)
1.06@ (1.02–1.11)
1.02 (0.98–1.05)
CRP mg/L ≥ 1.0
1.09# (1.03–1.15)
1.04* (1.01–1.07)
1.05@ (0.98–1.13)
1.01 (0.98–1.04)
0.96 (0.90–1.03)
1.0 (0.97–1.04)
BMI ≥ 30
1.18# (1.10–1.27)
1.06# (1.02–1.10)
1.18# (1.09–1.27)
1.06# (1.02–1.09)
1.15# (1.06–1.24)
1.04* (1.0–1.07)
Odd ratio (OR); confidence interval (CI); premenopausal women (PRE); postmenopausal women (POST); metabolic syndrome (MetS); blood pressure (BP); !elevated BP or hypertension treatment. According to chi-square statistic all models achieved statistical goodness of fit. Wald test significance: ; ; . All ORs remained statistically significant after adjustment for age. Similar results were obtained when age was replaced by years since menopause in postmenopausal women. Model adjusted for age and BMI (except BMI when modeling associations for elevated BMI and elevated WC). Multivariate logistic regression model adjusted for age, BMI, smoking, physical activity, HOMA-1, SBP, and TG/HDL-C ratio (except BMI when modeling associations for elevated BMI and elevated WC; except HOMA-IR when modeling associations for elevated glucose and elevated HOMA-IR; except SBP when modeling association for elevated BP; except TG/HDL-C ratio when modeling associations for elevated TG, decreased HDL-C, elevated TG/HDL-ratio, and elevated TC/HDL-C ratio).
