Research Article

Azadirachta indica Attenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress

Figure 4

H&E staining showing histopathological damage induced by CP on the kidney of rats. (a) Control kidney section with normal renal corpuscle and renal tubules. (b) Rats treated with cisplatin with congested shrank and completely degenerated glomeruli, debris in the lumen of some renal tubules, and pyknotic nuclei in renal tubules. ((c) and (d)) Treatment with methanolic leaves extract of neem before or after administration of CP showing normal renal corpuscle and renal tubule more or less like normal structure (X 400). SG: shrank glomeruli, DG: degenerated glomeruli; D: debris; PN: pyknotic nuclei.