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BioMed Research International
Volume 2014, Article ID 647541, 9 pages
Review Article

Tumour Markers and Kidney Function: A Systematic Review

1Nephrology and Dialysis Unit, University Hospital “Magna Graecia”, 88100 Catanzaro, Italy
2CNR Institute of Clinical Physiology (IFC), 89100 Reggio Calabria, Italy

Received 16 August 2013; Revised 2 December 2013; Accepted 6 December 2013; Published 6 February 2014

Academic Editor: Shigeru Satoh

Copyright © 2014 Giuseppe Coppolino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumour markers represent useful tools in diagnosis and clinical management of patients with cancer, because they are easy to use, minimally invasive, and easily measured in either blood or urine. Unfortunately, such an ideal marker, as yet, does not exist. Different pathological states may increase the level of a tumour marker in the absence of any neoplasia. Alternatively, low levels of tumour markers could be also found in the presence of neoplasias. We aimed at reviewing studies currently available in the literature examining the association between tumour markers and different renal impairment conditions. Each tumour marker was found to be differently influenced by these criteria; additionally we revealed in many cases a lack of available published data.