In Vitro and In Vivo Effects of Suppressor of Cytokine Signalling 7 Knockdown in Breast Cancer: The Influence on Cellular Response to Hepatocyte Growth Factor

Table 3

The in vitro growth of MCF7 cells as measured by spectrophotometric light absorbance at a wavelength of 540 nm. Values represent mean (SD).

Cell lines		MCF7^ΔSOCS7			𝑃
	Incubation medium	Serum free only
MCF7^WT	Serum free only	0.86  (0.12)  vs. 0.54 (0.04)			0.037
MCF7^pEF6		0.86  (0.12)  vs. 0.58 (0.1)			0.009
		HGF
MCF7^WT	HGF	1.3  (0.25)  vs. 0.9 (0.1)			0.005
MCF7^pEF6		1.3  (0.25)  vs. 0.86 (0.1)			0.002
		Pretreatment with U73122 then HGF
MCF7^WT	Pretreatment with U73122 then HGF	0.85  (0.02)  vs. 0.74 (0.25)			0.4
MCF7^pEF6		0.85  (0.02)  vs. 0.71 (0.17)			0.26
Cell lines		MCF7^WT	MCF7^pEF6	MCF7^ΔSOCS7	𝑃
			HGF
MCF7^WT	Serum free only	0.9  (0.1)   vs. 0.54 (0.04)	0.86  (0.1)  vs. 0.54 (0.04)		0.007 & 0.015
MCF7^pEF6		0.9  (0.1)   vs. 0.58 (0.1)	0.86  (0.1)  vs. 0.58 (0.1)		0.015 & 0.03
MCF7^ΔSOCS7				1.3  (0.25)  vs. 0.86 (0.12)	0.002